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pentobarbital improves toxicity of ifosfamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. CYP3A4 inducers may perhaps increase the metabolism of ifosfamide to its active alkylating metabolites.pentobarbital will decrease the level or outcome of norgestrel by affecting hepatic/intestinal enzyme CYP3A4 metabol